Description

Benzene, 2-(Chloromethyl)-3,4-Difluoro-1-Methoxy- is a high-purity, multi-functional aromatic building block characterized by its unique substitution pattern. This compound is critical for advanced organic synthesis, offering a versatile scaffold for constructing complex molecules in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical and life sciences industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, leveraging the difluoro and methoxy motifs for bioactivity.
• Liquid Crystal & OLED Materials: Acts as a specialized monomer for creating advanced electronic materials, where its aromatic core and halogen substituents influence molecular alignment and electronic properties.
• Cross-Coupling Reactions: The chloromethyl group provides an excellent handle for further functionalization via palladium-catalyzed reactions like Suzuki-Miyaura or Buchwald-Hartwig amination.
• Polymer Modification: Employed to introduce functional side chains into polymer backbones, enhancing material properties for specialty coatings and engineering plastics.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.

Basic Information

Product Name	Benzene, 2-(Chloromethyl)-3,4-Difluoro-1-Methoxy-
CAS No.	1073435-67-2
Molecular Formula	C8H7ClF2O
Molecular Weight	192.59 g/mol
Synonyms	1-Methoxy-2-(chloromethyl)-3,4-difluorobenzene; 3,4-Difluoro-2-(chloromethyl)-1-methoxybenzene; 2-(Chloromethyl)-3,4-difluoroanisole; 3,4-Difluoro-2-(chloromethyl)anisole; (3,4-Difluoro-2-methoxyphenyl)methyl chloride; 1-(Chloromethyl)-2-methoxy-3,4-difluorobenzene
EINECS	Contact for details

Quality Control

Every batch of Benzene, 2-(Chloromethyl)-3,4-Difluoro-1-Methoxy- is manufactured under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.