Description

E-2-(3-Trifluoromethylphenyl)Vinylboronic Acid Pinacol Ester is a high-purity, advanced boronic ester building block crucial for modern synthetic chemistry. This compound is specifically engineered for use in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality reagents for drug discovery and specialty chemical synthesis.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds to introduce the (3-trifluoromethylphenyl)vinyl moiety into target molecules.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl and vinyl groups for enhanced bioactivity and metabolic stability.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as OLEDs and semiconductors, where its structural motifs can tune electronic properties.
• Ligand and Catalyst Development: Useful for constructing complex ligands used in asymmetric catalysis and organometallic chemistry.
• Chemical Biology Probes: Acts as a versatile handle for bioconjugation and the development of molecular probes for imaging and diagnostic applications.

Basic Information

Product Name	E-2-(3-Trifluoromethylphenyl)Vinylboronic Acid Pinacol Ester
CAS No.	1073354-88-7
Molecular Formula	C₁₅H₁₈BF₃O₂
Molecular Weight	298.11 g/mol
Synonyms	(E)-2-(3-(Trifluoromethyl)phenyl)ethene-1,1-diylbis(oxy)bis(2,3-dimethylbutane); (E)-2-(3-Trifluoromethylstyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (E)-[2-[3-(Trifluoromethyl)phenyl]ethenyl]boronic Acid Pinacol Ester; trans-2-(3-Trifluoromethylphenyl)vinylboronic Acid Pinacol Ester; B-[2-[3-(Trifluoromethyl)phenyl]ethenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (E)-2-(3-(Trifluoromethyl)phenyl)vinylboronate
EINECS	Contact for details

Quality Control

Our E-2-(3-Trifluoromethylphenyl)Vinylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is analyzed using advanced techniques including NMR, HPLC, and GC to confirm identity, isomeric purity (E/Z ratio), and assay. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when possible for long-term stability. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Isomeric Purity (E/Z ratio, HPLC)	≥95:5 (E:Z)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.