Description

2-Fluoro-4-Trifluoromethylphenylboronic Acid, Pinacol Ester is a high-purity, synthetically valuable organoboron reagent. This compound is essential as a key building block in modern cross-coupling reactions, enabling the efficient synthesis of complex fluorinated aromatic structures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries.

Application

• Pharmaceutical Intermediate: A critical precursor in Suzuki-Miyaura cross-coupling reactions for constructing novel drug candidates, particularly those requiring fluorinated aromatic motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the introduction of fluorine and trifluoromethyl groups improves activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for creating fluorinated organic semiconductors, charge-transport materials, and emissive layers in display and lighting technologies.
• Polymer Chemistry: Incorporated into specialty polymers to impart unique properties such as chemical resistance, thermal stability, and specific optical characteristics.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D focused on organometallic chemistry, catalysis, and the synthesis of complex organic molecules.
• Fluorine Chemistry: A valuable synthon for introducing both fluorine and a boronic ester functional group, allowing for further selective derivatization in multi-step synthetic routes.

Basic Information

Product Name	2-Fluoro-4-Trifluoromethylphenylboronic Acid, Pinacol Ester
CAS No.	1073353-68-0
Molecular Formula	C₁₃H₁₅BF₄O₂
Molecular Weight	290.07 g/mol
Synonyms	2-Fluoro-4-(trifluoromethyl)benzeneboronic acid pinacol ester; (2-Fluoro-4-(trifluoromethyl)phenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[2-fluoro-4-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane; 2-(2-Fluoro-4-trifluoromethylphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane; Pinacol 2-Fluoro-4-(trifluoromethyl)phenylboronate; Boronic acid, B-[2-fluoro-4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester (9CI); 2-Fluoro-4-trifluoromethylphenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Trifluoromethylphenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.