Description

n-[2-(S)-Methyl-D3-Butyryl]-4-(S)-Phenylmethyl-2-Oxazolidinone is a high-purity, isotopically labeled chiral auxiliary and synthetic intermediate. This compound is critical for enabling precise stereochemical control and deuterium labeling in advanced organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical companies engaged in process chemistry, medicinal chemistry, and the synthesis of deuterated drug candidates.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Employed for the stereoselective construction of complex molecules, ensuring high enantiomeric excess in critical synthetic steps.
• Deuterated Pharmaceutical Intermediate: Serves as a key building block for incorporating stable deuterium (D) isotopes into drug molecules to potentially improve metabolic stability, pharmacokinetics, and safety profiles.
• Process Research & Development (R&D): Used in route scouting and optimization for the scalable synthesis of target compounds under GMP or non-GMP conditions.
• Medicinal Chemistry & Lead Optimization: Facilitates the creation of analog libraries for structure-activity relationship (SAR) studies, especially where isotopic labeling is required.
• Reference Standard & Analytical Testing: Acts as a high-purity standard for method development and quality control (HPLC, GC, NMR) in analytical laboratories.
• Academic Research: Supports investigations in novel synthetic methodologies, catalysis, and mechanistic studies within university and institutional labs.

Basic Information

Product Name	n-[2-(S)-Methyl-D3-Butyryl]-4-(S)-Phenylmethyl-2-Oxazolidinone
CAS No.	1073232-99-1
Molecular Formula	C15H16D3NO3
Molecular Weight	262.34 g/mol (approx.)
Synonyms	(4S)-4-Benzyl-3-[(2S)-2-methyl-1-oxo-2,2,3,3,3-pentadeuteriobutyl]-1,3-oxazolidin-2-one; (S)-4-Benzyl-3-[(S)-2-methyl-1-oxo-2,2,3,3,3-pentadeuteriobutyl]oxazolidin-2-one; Evans Auxiliary, Deuterated; (S)-4-Benzyl-3-[(S)-2-methyl-D3-butyryl]-2-oxazolidinone; Deuterated Evans Chiral Auxiliary; D3-Labeled Evans Auxiliary; (4S)-Benzyl-3-[(2S)-2-methyl-D3-butyryl]oxazolidin-2-one
EINECS	Contact for details

Quality Control

Our n-[2-(S)-Methyl-D3-Butyryl]-4-(S)-Phenylmethyl-2-Oxazolidinone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for chemical and chiral purity, NMR (¹H, ¹³C, ²H) for structural and isotopic confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment and allowed to reach ambient temperature before opening to prevent moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure (¹H, ¹³C, ²H)
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Deuterium Incorporation (MS/NMR)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.