Description

4-(Aminomethyl)-3-Fluorophenylboronic Acid is a specialized bifunctional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a boronic acid and a primary amine group on a fluorinated aromatic ring, makes it a versatile reagent for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for applications in Suzuki-Miyaura cross-coupling reactions and as a precursor for functionalized materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery programs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for creating biaryl and heterobiaryl structures, a cornerstone reaction in medicinal chemistry.
• Ligand and Catalyst Development: Used in the preparation of novel ligands for catalysis and metal-organic frameworks (MOFs) due to its chelating amine-boronic acid functionality.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides and fungicides that require fluorinated aromatic components.
• Material Science Precursor: Employed in the synthesis of organic electronic materials and polymers where fluorination and boronic acid groups impart specific electronic properties.
• Bioconjugation and Probe Synthesis: The amine group allows for facile conjugation to biomolecules or fluorescent tags, creating molecular probes for diagnostic applications.

Basic Information

Product Name	4-(Aminomethyl)-3-Fluorophenylboronic Acid
CAS No.	1073055-69-2
Molecular Formula	C7H9BFNO2
Molecular Weight	168.96 g/mol
Synonyms	(3-Fluoro-4-(aminomethyl)phenyl)boronic acid; 4-(Aminomethyl)-3-fluorobenzeneboronic acid; 3-Fluoro-4-(aminomethyl)benzeneboronic acid; B-(3-Fluoro-4-(aminomethyl)phenyl)boronic acid; 4-(Aminomethyl)-3-fluorophenyl-Boronic Acid; 3-Fluoro-4-(aminomethyl)phenylboronic acid pinacol ester (protected form); 1073055-69-2
EINECS	Contact for details

Quality Control

Our 4-(Aminomethyl)-3-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.