Description

3-Amino-4,5-Difluorophenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its molecular structure, featuring both an amino group and a boronic acid moiety on a difluorinated aromatic ring, makes it an indispensable reagent for constructing complex molecules via cross-coupling reactions. This compound is primarily sought after by research institutions and industrial R&D departments engaged in the development of pharmaceuticals, agrochemicals, and advanced materials, where it enables the precise introduction of functionalized aromatic systems.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Ligand for Catalysis: Can be utilized to develop novel ligands for transition metal catalysts used in asymmetric synthesis.
• Material Science Research: Serves as a monomer or building block for constructing organic frameworks, polymers, and liquid crystals with specific electronic or optical properties.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and sensors for studying biological processes, leveraging its boronic acid group's affinity for diols.
• Organic Electronic Materials: A potential component in the development of organic semiconductors and light-emitting materials due to its conjugated system and functional handles.

Basic Information

Item	Detail
Product Name	3-Amino-4,5-Difluorophenylboronic Acid
CAS No.	1072952-10-3
Molecular Formula	C6H6BF2NO2
Molecular Weight	172.93 g/mol
Synonyms	3-Amino-4,5-difluorobenzeneboronic acid; (3-Amino-4,5-difluorophenyl)boronic acid; 4,5-Difluoro-3-aminophenylboronic acid; Boronic acid, B-(3-amino-4,5-difluorophenyl)-; 3-Amino-4,5-difluorophenyl-B(OH)2; 1072952-10-3; 3-Amino-4,5-difluoro phenyl boronic acid
EINECS	Contact for details

Quality Control

Every batch of 3-Amino-4,5-Difluorophenylboronic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure high purity and batch-to-batch consistency. Our standard quality commitment includes providing a detailed Certificate of Analysis (COA) with each shipment, which reports key parameters such as assay purity and impurity profiles. We adhere to relevant industry standards for fine chemical intermediates, and custom purity grades (e.g., >97%, >98%, >99%) can be supplied to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.