Description

4,5-Difluoro-2-isopropoxyphenylboronic acid is a high-value organoboron building block, specifically a substituted phenylboronic acid derivative. This compound is essential as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl structures in modern synthetic chemistry. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex difluorinated biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: A key reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4,5-Difluoro-2-isopropoxyphenylboronic Acid
CAS No.	1072951-61-1
Molecular Formula	C9H11BF2O3
Molecular Weight	216.00 g/mol
Synonyms	(4,5-Difluoro-2-isopropoxyphenyl)boronic acid; 2-Isopropoxy-4,5-difluorophenylboronic acid; 4,5-Difluoro-2-(1-methylethoxy)benzeneboronic acid; B-(4,5-Difluoro-2-isopropoxyphenyl)boronic acid; CAS 1072951-61-1; Boronic acid, B-(4,5-difluoro-2-isopropoxyphenyl)-
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2-isopropoxyphenylboronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of GMP environments for non-GMP starting materials and supports regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.