Description

5-Bromo-2-(trifluoromethoxy)phenylboronic acid is a high-value organoboron building block, specifically a substituted phenylboronic acid derivative. This compound is essential for modern synthetic chemistry, enabling the formation of carbon-carbon bonds via the versatile Suzuki-Miyaura cross-coupling reaction. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex biaryl or heterobiaryl structures for therapeutic applications.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific halogenated and fluorinated aromatic motifs for enhanced activity.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and semiconductors, where the bromo and trifluoromethoxy groups tune electronic properties.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and inhibitors for studying biological pathways and enzyme functions.
• Ligand and Catalyst Preparation: Acts as a starting material for the synthesis of specialized ligands used in catalysis and coordination chemistry.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects requiring this precise boronic acid.

Basic Information

Product Name	5-Bromo-2-(trifluoromethoxy)phenylboronic Acid
CAS No.	1072951-56-4
Molecular Formula	C7H5BBrF3O3
Molecular Weight	284.83 g/mol
Synonyms	[5-Bromo-2-(trifluoromethoxy)phenyl]boronic acid; (5-Bromo-2-(trifluoromethoxy)phenyl)boronic acid; 2-Bromo-5-(trifluoromethoxy)benzeneboronic acid; 5-Bromo-2-trifluoromethoxybenzeneboronic acid; Boronic acid, B-[5-bromo-2-(trifluoromethoxy)phenyl]-; 1072951-56-4; AKOS026710915
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(trifluoromethoxy)phenylboronic acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed specifications are provided for each lot to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF Titration)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.