Description

2-Fluoro-5-Pentanoylphenylboronic Acid is a specialized boronic acid derivative featuring both a fluorine substituent and a pentanoyl (valeryl) group, making it a valuable building block in modern synthetic chemistry. This compound is crucial for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl structures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated biaryl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the specific substitution pattern can influence biological activity and selectivity.
• Material Science Research: Serves as a precursor for constructing organic electronic materials, such as those used in OLEDs and organic photovoltaics, due to its ability to form conjugated systems.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Ligand Synthesis for Catalysis: Utilized to create sophisticated ligands for transition metal catalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A critical component for custom synthesis houses serving the life sciences sector, enabling the production of bespoke compounds for client R&D.

Basic Information

Product Name	2-Fluoro-5-Pentanoylphenylboronic Acid
CAS No.	1072951-52-0
Molecular Formula	C₁₁H₁₄BFO₃
Molecular Weight	224.04 g/mol
Synonyms	(2-Fluoro-5-pentanoylphenyl)boronic acid; 5'-Valeryl-2'-fluorobenzeneboronic acid; 2-Fluoro-5-valerylbenzeneboronic acid; 2-Fluoro-5-(1-oxopentyl)benzeneboronic acid; 2-Fluoro-5-pentanoylbenzeneboronic acid; 2-Fluoro-5-valerylphenylboronic acid; Boronic acid, B-(2-fluoro-5-pentanoylphenyl)-
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Pentanoylphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%
Boronic Acid Assay (NMR/Titration)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.