Description

2-Hydroxy-4-(Trifluoromethyl)Phenylboronic Acid is a specialized organoboron compound featuring a phenolic hydroxyl group and a trifluoromethyl substituent, making it a versatile building block for advanced synthesis. This compound is particularly valued for its role in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl structures. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require high-purity intermediates for developing new active ingredients and functional materials. Our supply ensures consistent quality and reliable availability for your critical R&D and production needs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoromethyl groups which enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the boronic acid moiety enables efficient carbon-carbon bond formation.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: An essential reagent for palladium-catalyzed coupling reactions to form biaryl and heterobiaryl compounds, a fundamental reaction in medicinal chemistry.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and sensors for studying biological processes.
• Catalyst Ligand Development: The phenolic hydroxyl group can be modified to create novel ligands for transition metal catalysis.

Basic Information

Product Name	2-Hydroxy-4-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1072951-50-8
Molecular Formula	C7H6BF3O3
Molecular Weight	205.93 g/mol
Synonyms	[2-Hydroxy-4-(trifluoromethyl)phenyl]boronic acid; 2-(Trifluoromethyl)-4-boronophenol; 4-Trifluoromethylsalicylboronic Acid; (2-Hydroxy-4-trifluoromethylphenyl)boronic Acid; 2-Hydroxy-4-trifluoromethylbenzeneboronic Acid; B-[2-Hydroxy-4-(trifluoromethyl)phenyl]boronic Acid; 2-Hydroxy-α,α,α-trifluoro-p-tolueneboronic Acid
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-4-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality control protocols to ensure it meets the high-purity standards required for research and commercial synthesis. Each batch is analyzed using advanced techniques including HPLC, NMR, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We adhere to a quality management system and can support regulatory documentation needs for various markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.