Description

2,4,6-Trifluoro-3-Hydroxyphenylboronic Acid is a multifunctional boronic acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the unique combination of a boronic acid group for cross-coupling reactions and fluorine substituents that impart desirable electronic and metabolic properties to target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing complex, fluorinated biaryl structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used to create novel fluorinated pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Building block for synthesizing fluorinated organic electronic materials, such as those used in OLEDs and semiconductors.
• Ligand for Catalysis: Can be utilized to develop novel boronic acid-based ligands for asymmetric catalysis and molecular recognition.
• Fluorine-Containing Compound Library: Essential for medicinal chemistry research in constructing diverse compound libraries for high-throughput screening.
• Chemical Biology Probes: Serves as a handle for creating probes that target biomolecules, leveraging the boronic acid group's affinity for diols.

Basic Information

Product Name	2,4,6-Trifluoro-3-Hydroxyphenylboronic Acid
CAS No.	1072951-37-1
Molecular Formula	C6H4BF3O3
Molecular Weight	191.90 g/mol
Synonyms	(3-Hydroxy-2,4,6-trifluorophenyl)boronic acid; 2,4,6-Trifluoro-3-hydroxybenzeneboronic acid; 3-Borono-2,4,6-trifluorophenol; 2,4,6-Trifluoro-3-hydroxybenzeneboronic acid pinacol ester (common derivative); 2,4,6-Trifluoro-3-hydroxyphenyl-B(OH)2; 3-Hydroxy-2,4,6-trifluorophenylboronic acid; TFPBA (abbreviation)
EINECS	Contact for details

Quality Control

Our 2,4,6-Trifluoro-3-Hydroxyphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	Conforms
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.