Description

3-(tert-Butyldimethylsilyloxy)-2,4,6-Trifluorophenylboronic Acid is a sophisticated organoboron building block featuring a protected phenolic hydroxyl group and a boronic acid functionality. This compound is specifically engineered for advanced cross-coupling reactions, such as the Suzuki-Miyaura reaction, enabling the precise construction of complex fluorinated aromatic systems. It is an essential intermediate for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and materials science, where the introduction of fluorine atoms and specific substitution patterns is critical for modulating biological activity and material properties.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and CNS-targeted drugs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where fluorinated aromatic rings enhance stability and bioavailability.
• Materials Science Research: Serves as a precursor for synthesizing fluorinated organic semiconductors, liquid crystals, and polymers with tailored electronic and optical properties.
• Chemical Biology & Probe Development: Enables the synthesis of fluorinated molecular probes and tags for imaging and diagnostic applications.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to form biaryl and heterobiaryl linkages under mild conditions.
• Process Chemistry & Scale-up: Suitable for development from laboratory-scale research to pilot plant and commercial manufacturing processes.

Basic Information

Product Name	3-(tert-Butyldimethylsilyloxy)-2,4,6-Trifluorophenylboronic Acid
CAS No.	1072946-65-6
Molecular Formula	C₁₂H₁₇BF₃O₂Si
Molecular Weight	297.16 g/mol
Synonyms	2,4,6-Trifluoro-3-[(tert-butyldimethylsilyl)oxy]benzeneboronic Acid; (2,4,6-Trifluoro-3-((tert-butyldimethylsilyl)oxy)phenyl)boronic Acid; 3-(TBDMSO)-2,4,6-Trifluorophenylboronic Acid; 3-(tert-Butyldimethylsiloxy)-2,4,6-trifluorophenylboronic Acid; 2,4,6-Trifluoro-3-(tert-butyldimethylsilyloxy)phenylboronic Acid; TBDMS-protected Trifluorophenylboronic Acid; 3-[(1,1-Dimethylethyl)dimethylsilyl]oxy-2,4,6-trifluorobenzeneboronic Acid
EINECS	Contact for details

Quality Control

Our production of 3-(tert-Butyldimethylsilyloxy)-2,4,6-Trifluorophenylboronic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials undergo rigorous analytical testing, including NMR (¹H, ¹³C, ¹⁹F, ¹¹B), HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.