Description

5-(Aminomethyl)-2-Fluorophenylboronic Acid, Hydrochloride is a specialized bifunctional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a boronic acid group and a primary amine (as its hydrochloride salt), makes it an invaluable reagent for constructing complex molecular architectures via cross-coupling and bioconjugation strategies. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel fluorinated biaryl compounds targeted in drug discovery programs.
• Protease Inhibitor Synthesis: Used in the construction of boronic acid-based protease inhibitors, a promising class of therapeutics for conditions like cancer and inflammatory diseases.
• Bioconjugation & ADC Development: The amine functionality allows for linker attachment in the synthesis of Antibody-Drug Conjugates (ADCs) and other targeted biopharmaceuticals.
• Agrochemical Research: Serves as a building block for creating new fluorinated pesticides and herbicides with enhanced activity and environmental profile.
• Materials Science: Employed in the synthesis of functionalized organic frameworks and polymers where the boronic acid group enables dynamic covalent chemistry.
• Chemical Biology Probes: Utilized to develop activity-based probes for studying enzyme function and for carbohydrate sensing applications.

Basic Information

Product Name	5-(Aminomethyl)-2-Fluorophenylboronic Acid, Hydrochloride
CAS No.	1072946-46-3
Molecular Formula	C7H10BClFNO2
Molecular Weight	205.42 g/mol
Synonyms	(3-Fluoro-4-(aminomethyl)phenyl)boronic acid hydrochloride; 2-Fluoro-5-(aminomethyl)benzeneboronic acid HCl; 5-(Aminomethyl)-2-fluorobenzeneboronic acid hydrochloride; B-(3-Fluoro-4-(aminomethyl)phenyl)boronic acid hydrochloride; 4-(Aminomethyl)-2-fluorophenylboronic acid hydrochloride; (4-(Aminomethyl)-2-fluorophenyl)boronic acid hydrochloride; 2-Fluoro-5-(aminomethyl)phenylboronic acid hydrochloride
EINECS	Contact for details

Quality Control

Our 5-(Aminomethyl)-2-Fluorophenylboronic Acid, Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the stringent requirements for advanced research and cGMP starting material applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.