Description

3-(Aminomethyl)-2-Fluorophenylboronic Acid, Hydrochloride is a specialized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in the unique combination of a reactive boronic acid group and a protected primary amine, enabling efficient cross-coupling and subsequent functionalization. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules in drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds targeting central nervous system (CNS) disorders and oncology.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic acid functionality makes it an ideal partner for palladium-catalyzed cross-coupling to form biaryl and heterobiaryl structures, a cornerstone of medicinal chemistry.
• Peptidomimetic & Bioisostere Development: Used to incorporate fluorinated phenylalanine analogs and other novel scaffolds into peptide-like molecules to enhance metabolic stability and binding affinity.
• Agrochemical Synthesis: Employed in the research and production of advanced herbicides and fungicides that require specific fluorinated aromatic components.
• Ligand & Catalyst Development: Serves as a starting material for creating novel bidentate ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design and synthesis of fluorescent tags and activity-based probes for studying enzyme function and protein interactions.

Basic Information

Product Name	3-(Aminomethyl)-2-Fluorophenylboronic Acid, Hydrochloride
CAS No.	1072946-44-1
Molecular Formula	C7H10BClFNO2
Molecular Weight	205.42 g/mol
Synonyms	(3-(Aminomethyl)-2-fluorophenyl)boronic acid hydrochloride; 2-Fluoro-3-(aminomethyl)benzeneboronic acid HCl; B-(3-(Aminomethyl)-2-fluorophenyl)boronic acid hydrochloride; 3-(Aminomethyl)-2-fluorobenzeneboronic acid hydrochloride; (2-Fluoro-3-(aminomethyl)phenyl)boronic acid hydrochloride; 1072946-44-1; 3-Fluoro-2-borono-benzenemethanamine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 3-(Aminomethyl)-2-Fluorophenylboronic Acid, HCl is produced and tested under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency meet the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (Titration)	95.0% - 105.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.