Description

4-(1,3-Dioxolan-2-Yl)-2,6-Difluorophenylboronic Acid is a specialized organoboron compound featuring a protected aldehyde group and fluorine substituents, making it a valuable synthetic intermediate. This compound is engineered to facilitate efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental in constructing complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that benefit from the stability and reactivity of the boronic acid and difluorophenyl groups.
• Material Science Research: Serves as a precursor for organic electronic materials, including OLEDs and semiconductors, where fluorine atoms enhance stability and performance.
• Cross-Coupling Reactions: An essential reagent for Suzuki-Miyaura coupling to form biaryl and heterobiaryl structures central to many modern chemical processes.
• Chemical Biology Probes: Utilized in the development of molecular probes and sensors due to its specific reactivity and potential for further functionalization.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex boronic acids.

Basic Information

Product Name	4-(1,3-Dioxolan-2-Yl)-2,6-Difluorophenylboronic Acid
CAS No.	1072946-41-8
Molecular Formula	C9H9BF2O4
Molecular Weight	229.98 g/mol
Synonyms	2,6-Difluoro-4-(1,3-dioxolan-2-yl)phenylboronic Acid; [4-(1,3-Dioxolan-2-yl)-2,6-difluorophenyl]boronic Acid; 4-(1,3-Dioxolan-2-yl)-2,6-difluorobenzeneboronic Acid; 2,6-Difluoro-4-(2',5'-dioxolanyl)phenylboronic Acid; B-[4-(1,3-Dioxolan-2-yl)-2,6-difluorophenyl]boronic Acid
EINECS	Contact for details

Quality Control

Our 4-(1,3-Dioxolan-2-Yl)-2,6-Difluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every lot and provided upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.