Description

5-Chloro-2-Methyl-4-(Trifluoromethyl)Phenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require a reliable, high-quality intermediate for developing new active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting complex, fluorinated aromatic structures.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl and chloro substituents confer desirable biological activity and stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organometallic catalysts used in asymmetric synthesis and other advanced catalytic processes.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs (Organic Light-Emitting Diodes) and semiconductors, where its specific substitution pattern modifies electronic properties.
• Chemical Biology Probes: Utilized to create boronic acid-based probes and sensors for detecting biological analytes, leveraging its ability to form reversible complexes with diols.
• Custom Synthesis and Contract Manufacturing: Supplied to fine chemical companies for use in custom synthesis projects and scale-up production under cGMP conditions.

Basic Information

Product Name	5-Chloro-2-Methyl-4-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1072946-33-8
Molecular Formula	C9H7BClF3O2
Molecular Weight	250.41 g/mol
Synonyms	5-Chloro-2-methyl-4-(trifluoromethyl)benzeneboronic acid; (5-Chloro-2-methyl-4-(trifluoromethyl)phenyl)boronic acid; 2-Methyl-5-chloro-4-(trifluoromethyl)phenylboronic acid; 4-Trifluoromethyl-5-chloro-2-methylphenylboronic acid; Boronic acid, B-[5-chloro-2-methyl-4-(trifluoromethyl)phenyl]-; CAS 1072946-33-8
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Methyl-4-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance in sensitive cross-coupling applications. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.