Description

6-(4-Fluorophenyl)Pyridine-3-Boronic Acid is a high-value boronic acid derivative, a crucial building block in modern synthetic chemistry. Its primary value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly in the development of active pharmaceutical ingredients (APIs) and functional organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, especially those containing biphenyl or heterobiaryl motifs for oncology, CNS, and antiviral applications.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic systems for enhanced activity and selectivity.
• Material Science Research: Serves as a monomer or building block for constructing organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling: The principal application is as a boronic acid reagent for palladium-catalyzed carbon-carbon bond formation with aryl or vinyl halides.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and fluorescent tags for imaging and diagnostic applications.
• Catalyst Ligand Synthesis: Can be incorporated into the structure of sophisticated ligands used in asymmetric catalysis.

Basic Information

Product Name	6-(4-Fluorophenyl)Pyridine-3-Boronic Acid
CAS No.	1072944-20-7
Molecular Formula	C11H9BFNO2
Molecular Weight	217.01 g/mol
Synonyms	[6-(4-Fluorophenyl)-3-pyridinyl]boronic acid; (6-(4-Fluorophenyl)pyridin-3-yl)boronic acid; 3-Borono-6-(4-fluorophenyl)pyridine; 6-(p-Fluorophenyl)-3-pyridineboronic acid; 6-(4-Fluorophenyl)-3-pyridylboronic acid; 1072944-20-7; Boronic acid, B-[6-(4-fluorophenyl)-3-pyridinyl]-; 6-(4-Fluorophenyl)pyridine-3-boronic acid pinacol ester (protected form)
EINECS	Contact for details

Quality Control

Our 6-(4-Fluorophenyl)Pyridine-3-Boronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable, and each lot is accompanied by a comprehensive Certificate of Analysis (COA). The COA provides detailed results for purity (typically by HPLC), identity confirmation (by NMR and IR), and impurity profiling to meet the stringent requirements of our pharmaceutical and R&D clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Anhydrous basis)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.