Description

Fmoc-α-Me-Asp(Otbu)-Oh is a protected, non-natural amino acid derivative widely used in solid-phase peptide synthesis (SPPS). This compound is critical for introducing a methylated aspartic acid residue into peptide chains, enabling the study of structure-activity relationships and the development of novel bioactive peptides. It is an essential building block for researchers and manufacturers in pharmaceutical R&D, biotechnology, and academic research focused on peptide-based therapeutics and diagnostics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected building block for the controlled assembly of complex peptides.
• Pharmaceutical Research: Used in the discovery and development of peptide drugs, hormones, and enzyme inhibitors.
• Structure-Activity Relationship (SAR) Studies: Incorporates a methylated aspartate side chain to modulate peptide conformation, stability, and receptor binding.
• Bioconjugation and Labeling: Serves as a precursor for creating modified peptides with specific functional handles.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening.
• Academic and Institutional Research: Fundamental reagent for studies in organic chemistry, medicinal chemistry, and chemical biology.

Basic Information

Product Name	Fmoc-α-Me-Asp(Otbu)-Oh
CAS No.	1072845-47-6
Molecular Formula	C24H27NO6
Molecular Weight	425.48 g/mol
Synonyms	Fmoc-Asp(OMe)-OtBu; Fmoc-Aspartic acid β-tert-butyl ester α-methyl ester; N-(9-Fluorenylmethoxycarbonyl)-α-methylaspartic acid 4-tert-butyl ester; Fmoc-α-methyl-L-aspartic acid 4-tert-butyl ester; Fmoc-Asp(α-Me)-OtBu; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-2-methylbutanedioic acid 4-tert-butyl ester; N-α-Fmoc-α-methylaspartic acid β-tert-butyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-α-Me-Asp(Otbu)-Oh is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.