Description

1-(1,1-Difluoroethyl)-3-(Trifluoromethyl)Benzene is a high-value fluorinated aromatic building block characterized by its unique difluoroethyl and trifluoromethyl substituents. This compound is essential for introducing lipophilicity and metabolic stability into advanced molecular architectures, making it a critical intermediate in modern synthetic chemistry. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its ability to modify electronic properties and solubility.
• Chemical Biology & Proteomics: Employed as a tagging or labeling reagent in probe development for studying biological systems and protein interactions.
• Organic Synthesis: A versatile reagent for cross-coupling reactions, nucleophilic substitutions, and as a scaffold for constructing complex, fluorinated heterocycles.

Basic Information

Item	Details
Product Name	1-(1,1-Difluoroethyl)-3-(Trifluoromethyl)Benzene
CAS No.	1071212-33-3
Molecular Formula	C9H7F5
Molecular Weight	210.15 g/mol
Synonyms	3-(Trifluoromethyl)-α,α-difluoroethylbenzene; 1-(1,1-Difluoroethyl)-3-(trifluoromethyl)benzene; 1-Difluoroethyl-3-trifluoromethylbenzene; m-(Trifluoromethyl)phenyldifluoroethane; α,α-Difluoro-3-(trifluoromethyl)ethylbenzene; (3-Trifluoromethylphenyl)difluoroethane; Benzene, 1-(1,1-difluoroethyl)-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 1-(1,1-Difluoroethyl)-3-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. We employ advanced analytical techniques including GC, HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Total Impurities (GC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.