Description

Dpeg(R)8-Sata (S-Acetyl-Dpeg(R)8-Nhs Ester) is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an amine-reactive NHS ester and a thiol-reactive SATA group, separated by a discrete 8-unit PEG spacer. This compound is engineered for the controlled, site-specific conjugation of biomolecules, enabling the creation of stable, well-defined constructs. It is a critical reagent for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and peptide/protein modification, where precise linkage and solubility are paramount.

Application

• Antibody-Drug Conjugate (ADC) Linker: For the controlled attachment of cytotoxic payloads to monoclonal antibodies via lysine residues.
• PEGylation of Peptides and Proteins: To introduce hydrophilic PEG chains onto thiol-containing biomolecules, improving solubility, stability, and pharmacokinetics.
• Surface Functionalization: For modifying nanoparticles, biosensors, or microarray surfaces with amine-reactive groups for subsequent biomolecule immobilization.
• Crosslinking Agent: In the formation of hydrogels or polymer networks by reacting with both amine and thiol functional groups.
• Diagnostic Reagent Synthesis: For conjugating enzymes, fluorophores, or other reporter molecules to antibodies or proteins used in assays.
• Biomaterial Engineering: To create bioactive scaffolds with controlled ligand presentation for tissue engineering applications.

Basic Information

Product Name	Dpeg(R)8-Sata (S-Acetyl-Dpeg(R)8-Nhs Ester)
CAS No.	1070798-99-0
Molecular Formula	C46H78N4O22
Molecular Weight	1039.1 g/mol
Synonyms	S-Acetyl-DPEG®8-NHS ester; SATA-PEG8-NHS ester; N-(3-((2,5-Dioxopyrrolidin-1-yl)oxy)-3-oxopropyl)-N-(2-((2-(2-(2-(2-(2-(2-(2-(3-((2,5-dioxopyrrolidin-1-yl)oxy)-3-oxopropoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethyl)carbamoyl)ethyl)-2-acetamido-3-sulfanylpropanamide; Heterobifunctional PEG crosslinker, NHS-PEG8-SATA; Amine and Thiol Reactive PEG Linker; Discrete PEG8 SATA NHS Ester.
EINECS	Contact for details

Quality Control

Our Dpeg(R)8-Sata is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, critical for sensitive bioconjugation workflows. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional integrity. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical and diagnostic development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (NHS Ester)	≥ 90% of theoretical
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.