Description

D-Tryptophan, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-n-Methyl- is a specialized, high-purity protected amino acid derivative, essential for advanced peptide synthesis and pharmaceutical research. This compound, with CAS number 1070774-51-4, is a critical building block for the controlled introduction of the tryptophan side chain, offering enhanced stability and selectivity during complex coupling reactions. It is primarily required by research institutions, pharmaceutical development labs, and fine chemical manufacturers engaged in the production of novel therapeutic peptides, peptidomimetics, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of N-methyl tryptophan residues into peptide chains using Fmoc-chemistry protocols.
• Pharmaceutical Research & Development: Serves as a crucial building block in the synthesis of peptide-based drug candidates, including hormone analogs and enzyme inhibitors.
• Peptidomimetic Design: Used to create modified peptide structures with improved metabolic stability, bioavailability, and receptor binding affinity.
• Bioconjugation and Labeling: The reactive handles allow for site-specific modification of peptides for diagnostic or targeting applications.
• Academic and Industrial Research: Employed in chemical biology studies to probe protein-protein interactions and enzyme mechanisms.
• Fine Chemical Synthesis: An intermediate in the multi-step synthesis of complex organic molecules and specialized amino acid derivatives.

Basic Information

Item	Details
Product Name	D-Tryptophan, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-n-Methyl-
CAS No.	1070774-51-4
Molecular Formula	C₂₈H₂₆N₂O₄
Molecular Weight	454.52 g/mol
Synonyms	Fmoc-N-Me-D-Trp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-tryptophan; N-Fmoc-N-methyl-D-tryptophan; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-(1H-indol-3-yl)propanoic acid; Fmoc-N-methyl-D-tryptophane; N-Methyl-N-Fmoc-D-tryptophan; Nα-Fmoc-Nα-methyl-D-tryptophan; D-Tryptophan, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-
EINECS	Contact for details

Quality Control

Our D-Tryptophan, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-n-Methyl- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ISO standards for pharmaceutical intermediates, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.