Description

2-(Dicyclohexylphosphino)-3,6-Dimethoxy-2'-4'-6'-Tri-I-Propyl-1,1'-Biphenyl, Min. 98% Brettphos is a highly specialized, air-stable monodentate phosphine ligand widely recognized for its efficacy in challenging cross-coupling reactions. Its primary commercial value lies in enabling efficient and selective transformations, particularly for the synthesis of complex pharmaceutical intermediates and advanced materials. This high-purity ligand is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable performance in demanding catalytic cycles.

Application

• As a superior ligand for Buchwald-Hartwig amination reactions, enabling C–N bond formation in complex molecule synthesis.
• Catalyzing Suzuki-Miyaura cross-coupling reactions involving sterically hindered or electronically deactivated substrates.
• Facilitating C–O and C–S bond-forming reactions for the construction of ethers and thioethers.
• Use in academic and industrial R&D for method development and exploring new catalytic pathways.
• Key component in the synthesis of Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Application in the preparation of organic electronic materials and functional polymers.

Basic Information

Product Name	2-(Dicyclohexylphosphino)-3,6-Dimethoxy-2'-4'-6'-Tri-I-Propyl-1,1'-Biphenyl, Min. 98% Brettphos
CAS No.	1070663-78-3
Molecular Formula	C₃₅H₅₃O₂P
Molecular Weight	536.77 g/mol
Synonyms	BrettPhos; 2-(Dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl; BrettPhos Ligand; 2-Biphenylphosphine, 2'-(dicyclohexylphosphino)-3,6-dimethoxy-2,4,6-triisopropyl-1,1'-biphenyl; DavePhos; RuPhos; t-BuBrettPhos (related ligand class); Biarylphosphine Ligand.
EINECS	Contact for details

Quality Control

Our Brettphos ligand is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analysis, including HPLC for purity and NMR for structural confirmation, to meet the exacting standards required for synthetic chemistry applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized; therefore, containers should be flushed with inert gas after each opening to maintain purity and catalytic activity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 98.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.