Description

(2S,4R)-n-tert-Butoxycarbonylaminoacetyl-4-Hydroxyproline Methyl Ester is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical chiral building block, enabling the precise introduction of the 4-hydroxyproline moiety into complex molecular architectures. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing novel therapeutic peptides, peptidomimetics, and other bioactive molecules where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based therapeutics, including hormone analogs and enzyme inhibitors.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid derivative for the controlled, sequential assembly of complex peptides on resin.
• Solution-Phase Peptide Chemistry: Employed in the synthesis of peptide fragments and conjugates in solution, offering flexibility in coupling strategies.
• Peptidomimetic Design: Integral for creating stable, bioavailable mimics of natural peptides by incorporating the rigid, hydroxylated proline scaffold.
• Glycopeptide Synthesis: Acts as a precursor or building block for synthesizing glycopeptides where hydroxyproline serves as a glycosylation site.
• Bioconjugation & Probe Development: Useful for creating labeled peptides or peptide-drug conjugates for diagnostic and targeted delivery applications.
• Academic & Contract Research: Serves as a high-value reagent in academic laboratories and CROs (Contract Research Organizations) focused on medicinal chemistry and chemical biology.

Basic Information

Product Name	(2S,4R)-n-tert-Butoxycarbonylaminoacetyl-4-Hydroxyproline Methyl Ester
CAS No.	1070165-90-0
Molecular Formula	C13H22N2O6
Molecular Weight	302.33 g/mol
Synonyms	Boc-Ac-Hyp-OMe; (2S,4R)-1-[(tert-Butoxycarbonyl)amino]acetyl-4-hydroxy-2-pyrrolidinecarboxylic Acid Methyl Ester; Boc-Ac-4-Hyp-OMe; N-Boc-aminoacetyl-trans-4-hydroxy-L-proline Methyl Ester; Methyl (2S,4R)-1-[(2-{[(tert-butoxy)carbonyl]amino}acetyl]-4-hydroxypyrrolidine-2-carboxylate; Boc-Ac-4(R)-Hyp-OMe; (2S,4R)-Boc-Ac-Hyp-OMe
EINECS	Contact for details

Quality Control

Our (2S,4R)-n-tert-Butoxycarbonylaminoacetyl-4-Hydroxyproline Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical research and peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.