Description

(Z)-Ethyl 2-Benzamido-4,4,4-Trifluorobut-2-Enoate is a high-value trifluoromethylated building block and a key chiral intermediate in organic synthesis. Its structure, featuring a benzamido group and a strategically placed trifluoromethyl moiety, makes it a versatile precursor for constructing complex molecules with enhanced biological activity and metabolic stability. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of new drug candidates, particularly in areas like enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Serves as a key building block for novel herbicides, fungicides, and insecticides, leveraging the properties of the trifluoromethyl group.
• Advanced Material Research: Used in the synthesis of specialty chemicals and functional materials that require fluorinated components for specific physical properties.
• Academic & R&D Laboratories: Employed in methodological studies and as a model compound for developing new synthetic routes involving fluorinated olefins and amides.
• Custom Synthesis & Contract Manufacturing: A starting material for the bespoke production of complex, fluorinated target molecules for client-specific projects.

Basic Information

Item	Details
Product Name	(Z)-Ethyl 2-Benzamido-4,4,4-Trifluorobut-2-Enoate
CAS No.	1068146-76-8
Molecular Formula	C13H12F3NO3
Molecular Weight	287.24 g/mol
Synonyms	Ethyl (Z)-2-benzamido-4,4,4-trifluorobut-2-enoate; (Z)-Ethyl 2-Benzoylamino-4,4,4-trifluorobut-2-enoate; 2-Benzamido-4,4,4-trifluorobut-2-enoic Acid Ethyl Ester (Z-isomer); (Z)-Ethyl α-benzamido-β-trifluoromethylacrylate; (Z)-Ethyl 2-(Benzoylamino)-4,4,4-trifluorocrotonate; (Z)-Ethyl 4,4,4-trifluoro-2-(phenylformamido)but-2-enoate; (Z)-Ethyl 2-benzamido-4,4,4-trifluorocrotonate; (Z)-Ethyl 2-benzamido-4,4,4-trifluoro-2-butenoate
EINECS	Contact for details

Quality Control

Our (Z)-Ethyl 2-Benzamido-4,4,4-Trifluorobut-2-Enoate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We provide comprehensive analytical data, including HPLC purity, chiral purity (enantiomeric excess), and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications is available with each shipment and upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation by atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (Z-isomer)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.