Description

3,3'-Bis(Diphenylphosphino)-5,5',6,6',7,7',8,8'-Octahydro [2,2']Binaphthalene Chloroform Adduct, 99% is a high-purity, chiral bidentate phosphine ligand essential for advanced asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, critical for producing single-isomer intermediates in pharmaceutical and fine chemical synthesis. This product is specifically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel, high-value chiral compounds.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Used in the production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting central nervous system, cardiovascular, and metabolic diseases.
• Cross-Coupling Reactions: Facilitates asymmetric versions of Suzuki-Miyaura, Heck, and other C-C bond-forming reactions with high stereocontrol.
• Agrochemical Manufacturing: Enables the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel reaction pathways in asymmetric synthesis.
• Fine Chemical Production: Applied in the manufacture of chiral flavors, fragrances, and advanced materials requiring specific stereochemistry.

Basic Information

Product Name	3,3'-Bis(Diphenylphosphino)-5,5',6,6',7,7',8,8'-Octahydro [2,2']Binaphthalene Chloroform Adduct, 99%
CAS No.	1067889-87-5
Molecular Formula	C45H42Cl3P2
Molecular Weight	744.13 g/mol
Synonyms	H8-BINAP Chloroform Adduct; Octahydro-BINAP Chloroform Solvate; 5,5',6,6',7,7',8,8'-Octahydro-1,1'-binaphthyl-2,2'-diyl)bis(diphenylphosphine) Chloroform Adduct; (R)-(+)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-binaphthalene-2,2'-diylbis(diphenylphosphine) Chloroform Adduct; (S)-(-)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-binaphthalene-2,2'-diylbis(diphenylphosphine) Chloroform Adduct; H8-BINAP•CHCl3; Tetrahydro-BINAP Derivative Chloroform Complex
EINECS	Contact for details

Quality Control

Our 99% grade product undergoes rigorous analytical testing to ensure batch-to-batch consistency and purity for sensitive catalytic applications. Quality is verified via HPLC, NMR, and chiral analysis to confirm enantiomeric excess where applicable. A comprehensive Certificate of Analysis (COA) detailing purity, solvent content, and identity is provided with each shipment, supporting compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a freezer. The product is easily oxidized and moisture-sensitive; ensure containers are sealed immediately after use and stored in a cool, dry, well-ventilated area away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 99.0%
Chloroform Content	1.0 - 2.0 mol eq.
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.