Description

2-Methoxy-4,6-Bis(trifluoromethyl)phenylboronic Acid is a highly functionalized arylboronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in the unique combination of the electron-withdrawing trifluoromethyl groups and the methoxy substituent, which significantly influences its reactivity and stability in cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to introduce complex, fluorinated aromatic motifs into target molecules, a key strategy for modulating bioavailability and metabolic stability.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl groups enhance lipophilicity and biological activity.
• Material Science Research: Employed in the creation of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or monomers for specialty polymers.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing sophisticated ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes, leveraging the boronic acid group's affinity for diols.

Basic Information

Product Name	2-Methoxy-4,6-Bis(trifluoromethyl)phenylboronic Acid
CAS No.	1067228-89-0
Molecular Formula	C10H7BF6O3
Molecular Weight	300.97 g/mol
Synonyms	[2-Methoxy-4,6-bis(trifluoromethyl)phenyl]boronic acid; 2-Methoxy-α,α,α,α',α',α'-hexafluoro-m-xylene-4-boronic acid; (2-Methoxy-4,6-bis(trifluoromethyl)phenyl)boronic acid; Boronic acid, B-[2-methoxy-4,6-bis(trifluoromethyl)phenyl]-; 4,6-Bis(trifluoromethyl)-2-methoxyphenylboronic acid
EINECS	Contact for details

Quality Control

Our 2-Methoxy-4,6-Bis(trifluoromethyl)phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.