Description

(2S)-1-[(4R)-4,5-Dihydro-4-(1-Methylethyl)-2-Oxazolyl]-2-(Diphenylphosphino)Ferrocene CAS NO 1065474-88-5 is a highly specialized, chiral ferrocenyl phosphine-oxazoline ligand. This compound matters as a premier catalyst component for enabling highly enantioselective transformations in fine chemical and pharmaceutical synthesis. It is critically needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Hydrogenation Catalyst: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in API (Active Pharmaceutical Ingredient) synthesis.
• Asymmetric C-C Bond Formation: Employed in cross-coupling reactions, conjugate additions, and allylic substitutions to construct chiral centers.
• Pharmaceutical Intermediate Synthesis: Critical for the production of chiral drug candidates and complex natural product analogs.
• Agrochemical Manufacturing: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for methodological development in organic and organometallic chemistry laboratories.
• Catalyst Screening Libraries: A high-value component in ligand libraries for high-throughput screening of catalytic systems.

Basic Information

Product Name	(2S)-1-[(4R)-4,5-Dihydro-4-(1-Methylethyl)-2-Oxazolyl]-2-(Diphenylphosphino)Ferrocene
CAS No.	1065474-88-5
Molecular Formula	C28H28FeNOP
Molecular Weight	481.35 g/mol
Synonyms	(S,R)-FerroPHOX; (S,R)-Fe-Phox; (S,R)-Josiphos SL-J009-1; (S,R)-2-(Diphenylphosphino)-1-[(4R)-4-isopropyl-4,5-dihydrooxazol-2-yl]ferrocene; (S,R)-2-(Diphenylphosphino)-1-[(4R)-4-isopropyl-2-oxazolinyl]ferrocene; (S,R)-2-(Diphenylphosphino)-1-[(4R)-4-(1-methylethyl)-4,5-dihydro-2-oxazolyl]ferrocene; (S,R)-2-(Diphenylphosphino)-1-[(4R)-4-isopropyl-4,5-dihydrooxazol-2-yl]ferrocene; (S,R)-Ferrocenyl Phosphine-Oxazoline Ligand
EINECS	Contact for details

Quality Control

Our high-value chiral ligands are produced and handled under strict quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot undergoes rigorous analytical characterization, including HPLC for chiral purity and NMR for structural confirmation. We provide comprehensive Certificates of Analysis (COA) detailing all specifications to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and light-sensitive; allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.