Description

R-3,3'-Bis(3,5-Dimethylphenyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthyl-2,2'-Diyl Hydrogenphosphate is a sophisticated chiral phosphoric acid derivative, serving as a high-performance organocatalyst and chiral ligand. Its value lies in enabling highly enantioselective transformations, which are critical for the efficient synthesis of single-enantiomer pharmaceuticals and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Organocatalysis: Employed as a Bransted acid catalyst for enantioselective reactions including Friedel-Crafts alkylations, transfer hydrogenations, and Mannich-type reactions.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Chiral Ligand in Metal Complexes: Can be used to modify metal catalysts, enhancing enantioselectivity in cross-coupling and reduction reactions.
• Fine Chemical Production: Facilitates the production of enantiomerically pure flavors, fragrances, and advanced organic materials.
• Methodology Development: A valuable tool for academic and industrial research groups developing new catalytic asymmetric synthetic protocols.
• Scale-up Process Chemistry: Suitable for optimization and implementation in pilot plant and commercial-scale manufacturing due to its stability and predictable performance.

Basic Information

Product Name	R-3,3'-Bis(3,5-Dimethylphenyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthyl-2,2'-Diyl Hydrogenphosphate
CAS No.	1065214-95-0
Molecular Formula	C40H40O4P1*
Molecular Weight	624.71 g/mol*
Synonyms	(R)-3,3'-Bis(3,5-dimethylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; (R)-3,3'-Bis(3,5-dimethylphenyl)-H8-BINOL phosphate; (R)-3,3'-Di(3,5-dimethylphenyl)-H8-BINAP acid; Octahydro-BINOL-derived phosphoric acid; R-DM-H8-BINOL phosphoric acid; Chiral phosphoric acid catalyst (R,DM,H8); TRIP analogue (hydrogenated); Contact for details.
EINECS	Contact for details.

*Calculated molecular weight and formula. Contact us for confirmed specifications.

Quality Control

Our production of R-3,3'-Bis(3,5-Dimethylphenyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthyl-2,2'-Diyl Hydrogenphosphate adheres to stringent internal quality standards designed for research and process chemistry. Each batch is characterized by NMR, HPLC, and optical rotation analysis to confirm chemical identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all relevant parameters are provided with every shipment to ensure traceability and support your quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and catalytic activity. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.