Description

S-(+)-o-Desmethyl-Venlafaxine-D6 is a high-purity, deuterium-labeled internal standard critical for accurate quantitative bioanalysis. This compound is specifically designed for use in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) applications, providing unmatched precision and reliability in pharmacokinetic and metabolism studies. It is an essential tool for pharmaceutical R&D laboratories, clinical research organizations, and forensic toxicology units requiring definitive analysis of venlafaxine and its metabolites.

Application

• LC-MS/MS Internal Standard for the precise quantification of O-desmethylvenlafaxine (ODV) in biological matrices (plasma, serum, urine).
• Pharmacokinetic and Bioequivalence Studies to monitor drug and metabolite levels with high accuracy and reproducibility.
• Forensic and Clinical Toxicology analysis for the definitive identification and measurement of venlafaxine metabolites.
• Drug Metabolism and Disposition (DMPK) Research to study the metabolic pathways and clearance of venlafaxine.
• Method Development and Validation in analytical laboratories to establish robust, compliant testing protocols.
• Quality Control in Pharmaceutical Manufacturing for monitoring potential impurities or degradation products related to the desmethyl metabolite.

Basic Information

Product Name	S-(+)-o-Desmethyl-Venlafaxine-D6
CAS No.	1062609-99-7
Molecular Formula	C16H19D6NO2
Molecular Weight	269.42 g/mol
Synonyms	(S)-(+)-O-Desmethylvenlafaxine-d6; (S)-1-[2-(Dimethylamino)-1-(4-phenoxyphenyl)ethyl]cyclohexanol-d6; (S)-O-Desmethylvenlafaxine D6; Desvenlafaxine-d6 (S-enantiomer); S-ODV D6; Deuterated Desvenlafaxine Impurity Standard; Venlafaxine Metabolite-d6; Pristiq-d6 (S-isomer)
EINECS	Contact for details

Quality Control

Every batch of S-(+)-o-Desmethyl-Venlafaxine-D6 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, verified by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, isotopic enrichment, and chromatographic data to support your regulatory submissions and method validation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.