Description

R-(-)-o-Desmethyl-Venlafaxine-D6 is a high-purity, deuterium-labeled internal standard critical for precise analytical quantification. This compound is specifically designed for use in bioanalytical research and pharmaceutical development, offering unmatched accuracy in mass spectrometry and chromatography. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, forensic toxicology, and clinical diagnostics sectors who require reliable reference materials for method development and validation.

Application

• Bioanalytical Method Development: Serves as a stable isotope-labeled internal standard for the accurate quantification of O-desmethylvenlafaxine (ODV) and related metabolites in biological matrices (e.g., plasma, serum, urine) via LC-MS/MS and GC-MS.
• Pharmacokinetic and Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug metabolism and clearance rates in clinical and preclinical research studies.
• Forensic and Clinical Toxicology: Used for the definitive identification and measurement of venlafaxine and its metabolites in forensic analysis and therapeutic drug monitoring (TDM).
• Pharmaceutical Quality Control: Acts as a reference standard for the assay and impurity profiling of active pharmaceutical ingredients (APIs) and finished drug products containing venlafaxine.
• Metabolite Identification and Characterization: Aids in the structural elucidation and pathway analysis of venlafaxine metabolites during drug development.
• Regulatory Compliance and Submission: Supports data packages for regulatory filings (e.g., FDA, EMA) by providing validated analytical methods with high specificity and accuracy.

Basic Information

Product Name	R-(-)-o-Desmethyl-Venlafaxine-D6
CAS No.	1062609-96-4
Molecular Formula	C16H19D6NO2
Molecular Weight	269.41 g/mol
Synonyms	(R)-(-)-O-Desmethylvenlafaxine-d6; (R)-1-[2-(Dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol-d6; O-Desmethylvenlafaxine-d6 (R-enantiomer); ODV-d6 (R-); Deuterated (R)-O-desmethylvenlafaxine; (R)-ODV-d6; Major Venlafaxine Metabolite-d6 (R-form); [Ring-D6]-(R)-O-Desmethylvenlafaxine
EINECS	Contact for details

Quality Control

Every batch of R-(-)-o-Desmethyl-Venlafaxine-D6 is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with the high-purity standards required for reference materials and internal standards in regulated environments. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% by HPLC), isotopic enrichment, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.