Description

D,L-o-Desmethyl Venlafaxine-D10 is a deuterium-labeled analog of a key metabolite of the antidepressant venlafaxine. This compound is of critical importance as a high-purity reference standard for analytical research and development. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development and validation.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical, stable-isotope labeled internal standard for the precise quantification of O-desmethylvenlafaxine (ODV) in biological matrices, ensuring accuracy and reproducibility in bioanalytical assays.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used in mass spectrometry-based studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of venlafaxine and its metabolites.
• Bioanalytical Method Development & Validation: Essential for developing, optimizing, and validating robust HPLC-MS/MS methods for therapeutic drug monitoring (TDM) and clinical research.
• Pharmaceutical Impurity Profiling: Acts as a reference marker in the identification and characterization of related substances and degradation products during drug substance and product development.
• Forensic and Clinical Toxicology: Employed in confirmatory testing and quantitative analysis of venlafaxine and its metabolites in forensic and clinical laboratory settings.
• Metabolite Synthesis and Research: Used as a precursor or reference compound in the synthesis and study of other labeled or unlabeled metabolites for advanced research applications.

Basic Information

Product Name	D,L-o-Desmethyl Venlafaxine-D10
CAS No.	1062607-49-1
Molecular Formula	C16D10H15NO2
Molecular Weight	~277.4 g/mol
Synonyms	O-Desmethylvenlafaxine-d10; ODV-d10; Desvenlafaxine-d10; (R/S)-1-[2-(Dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol-d10; 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol-d10; Didesmethyl Venlafaxine-d10; Pristiq-d10 (labeled analog); Major Venlafaxine Metabolite-d10
EINECS	Contact for details

Quality Control

Every batch of D,L-o-Desmethyl Venlafaxine-D10 is manufactured and tested under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing purity, isotopic purity (D-content), and analytical results are provided with each shipment to ensure compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.