Description

D,L-o-Desmethyl Venlafaxine-D6 is a deuterated isotopologue of a key metabolite of the antidepressant venlafaxine. This compound is of significant value as a high-purity internal standard for quantitative bioanalytical methods, ensuring accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug development and therapeutic drug monitoring.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantification of O-desmethylvenlafaxine in biological matrices.
• Critical reference material for pharmacokinetic (PK) and bioequivalence studies related to venlafaxine and its metabolites.
• Essential component in drug metabolism and disposition (DMPK) research to understand the metabolic pathways of venlafaxine.
• Used in the development and validation of clinical diagnostic assays for therapeutic drug monitoring (TDM) of antidepressants.
• Supports forensic and toxicological analysis for the accurate detection and measurement of venlafaxine and its metabolites.
• Valuable for academic and industrial research investigating the pharmacology and neurochemistry of serotonin-norepinephrine reuptake inhibitors (SNRIs).

Basic Information

Item	Detail
Product Name	D,L-o-Desmethyl Venlafaxine-D6
CAS No.	1062605-69-9
Molecular Formula	C16H19D6NO2
Molecular Weight	269.41 g/mol
Synonyms	O-Desmethylvenlafaxine-d6; Desvenlafaxine-d6; (R/S)-O-Desmethylvenlafaxine-d6; 1-[2-(Dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol-d6; D6-Labelled ODV; D,L-ODV-d6; Major Venlafaxine Metabolite-d6
EINECS	Contact for details

Quality Control

Every batch of D,L-o-Desmethyl Venlafaxine-D6 is manufactured and tested to meet the stringent requirements for analytical reference standards. Our quality assurance includes rigorous testing for isotopic purity, chemical purity, and identity to ensure consistency and reliability for your most sensitive LC-MS/MS applications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.