Description

(S)-Fmoc-2-Amino-5-(N'-Pbf-N''-Trifluoroethyl-Guanidino)-Pentanoic Acid is a sophisticated, orthogonally protected arginine derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is engineered to provide exceptional control and efficiency in the assembly of complex peptides, particularly those requiring selective deprotection strategies. It is an essential building block for researchers and manufacturers in pharmaceutical development, bioconjugation, and proteomics, enabling the creation of novel therapeutic peptides and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of peptides containing arginine residues.
• Pharmaceutical R&D: Critical intermediate in the development of peptide-based drugs, including hormone analogs, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation: Used to introduce guanidino functional groups into proteins, antibodies, or other biomolecules for labeling or functionalization.
• Proteomics Research: Synthesis of custom peptide standards, substrates, or probes for mass spectrometry and enzymatic studies.
• Combinatorial Chemistry: Building block for generating diverse peptide libraries for high-throughput screening against biological targets.
• Glycopeptide Synthesis: Facilitates the synthesis of complex peptides where the arginine side chain must be selectively addressed in the presence of other reactive groups.

Basic Information

Product Name	(S)-Fmoc-2-Amino-5-(N'-Pbf-N''-Trifluoroethyl-Guanidino)-Pentanoic Acid
CAS No.	1060769-47-2
Molecular Formula	C₃₈H₄₅F₃N₄O₇S
Molecular Weight	746.85 g/mol
Synonyms	Fmoc-Arg(Pbf-CF3)-OH; Fmoc-NG,NG'-bis(Pbf)-NG''-(2,2,2-trifluoroethyl)-L-arginine; N-α-Fmoc-Nω-{N',N''-bis[2,2,2-trifluoro-1-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]guanidino}-L-ornithine (protected form); Fmoc-L-arginine(Pbf-CF3)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((((2,2,2-trifluoroethyl)amino)((2,2,2-trifluoro-1-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl)amino)methylene)amino)pentanoic acid; Protected Fmoc-Arginine derivative; SPPS Arginine building block.
EINECS	Contact for details

Quality Control

This high-purity amino acid derivative is manufactured under strict quality control protocols suitable for sensitive research and development applications. Every batch is characterized by HPLC, NMR, and mass spectrometry to confirm identity, purity, and chiral integrity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. The product is moisture-sensitive and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation. Keep away from strong bases and organic solvents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0%
Optical Rotation	Specific range provided on COA
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.