Description

6-Ethynyl-2,3-Dihydro-Benzo[1,4]Dioxine is a high-purity organic building block featuring a fused benzodioxine core with a terminal alkyne functional group. This compound is a critical intermediate in modern pharmaceutical and advanced materials research, enabling the construction of complex molecular architectures via click chemistry and cross-coupling reactions. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for synthesizing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and inflammation.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators that require the benzodioxine scaffold.
• Material Science: Serves as a monomer or cross-linker in the production of specialty polymers, resins, and advanced organic electronic materials.
• Click Chemistry Reagent: The terminal alkyne group makes it an ideal substrate for Huisgen cycloaddition (copper-catalyzed azide-alkyne cycloaddition) to create triazole linkages.
• Ligand Synthesis: Used to prepare sophisticated ligands for catalysis and metal-organic frameworks (MOFs).
• Academic & Contract Research: Essential for exploratory organic synthesis and methodology development in university and CRO laboratories.

Basic Information

Product Name	6-Ethynyl-2,3-Dihydro-Benzo[1,4]Dioxine
CAS No.	1057670-26-4
Molecular Formula	C10H8O2
Molecular Weight	160.17 g/mol
Synonyms	6-Ethynyl-2,3-dihydro-1,4-benzodioxine; 2,3-Dihydro-6-ethynyl-1,4-benzodioxine; 6-Ethynyl-1,4-benzodioxane; 6-Ethynylbenzo-1,4-dioxane; 1057670-26-4; Ethynylbenzodioxine
EINECS	Contact for details

Quality Control

Our 6-Ethynyl-2,3-Dihydro-Benzo[1,4]Dioxine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to quality supports your regulatory and research needs, from early-stage discovery to process scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent potential oxidation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.