Description

1-Bromo-4-Chloro-2-(Difluoromethoxy)Benzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, chlorine, and a difluoromethoxy substituent, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and crop protection agent discovery.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores to modulate bioavailability and receptor binding.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance metabolic stability and activity.
• Material Science Precursor: Serves as a monomer or building block for specialty polymers and liquid crystals, contributing unique halogen-bonding and electronic characteristics.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination, leveraging the reactive bromine atom for selective functionalization.
• Fluorine Chemistry Research: A valuable compound for studying the influence of fluorine and fluorinated alkoxy groups on aromatic system reactivity and physical properties.
• Chemical Library Development: Employed in combinatorial and parallel synthesis to create diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Item	Detail
Product Name	1-Bromo-4-Chloro-2-(Difluoromethoxy)Benzene
CAS No.	1056942-37-0
Molecular Formula	C7H4BrClF2O
Molecular Weight	257.46 g/mol
Synonyms	4-Chloro-1-bromo-2-(difluoromethoxy)benzene; 2-Bromo-5-chloro-1-(difluoromethoxy)benzene; 1-Bromo-4-chloro-2-(difluoromethoxy)benzene; Benzene, 1-bromo-4-chloro-2-(difluoromethoxy)-; 2-(Difluoromethoxy)-1-bromo-4-chlorobenzene; 5-Chloro-2-bromo-1-(difluoromethoxy)benzene; 1056942-37-0
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Chloro-2-(Difluoromethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.