Description

2-(3,3-Difluorocyclobutyl)Ethan-1-Ol is a versatile fluorinated alcohol building block characterized by its cyclobutyl ring system. This compound is of significant interest in advanced organic synthesis, particularly for introducing difluorocyclobutyl motifs to modulate the physicochemical properties of target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting metabolic diseases and CNS disorders.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the difluorocyclobutyl group can enhance bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer Modification: Incorporated as a monomer or chain modifier to create specialty fluoropolymers with unique surface properties and chemical resistance.
• Ligand & Catalyst Development: Utilized in the preparation of chiral ligands and organocatalysts for asymmetric synthesis applications.

Basic Information

Product Name	2-(3,3-Difluorocyclobutyl)Ethan-1-Ol
CAS No.	1056467-54-9
Molecular Formula	C6H10F2O
Molecular Weight	136.14 g/mol
Synonyms	2-(3,3-Difluorocyclobutyl)ethanol; 3,3-Difluorocyclobutan-1-ylethanol; 2-(3,3-Difluorocyclobutyl)ethyl alcohol; (3,3-Difluorocyclobutyl)methanol, homologue; 1056467-54-9; 2-(3,3-Difluorocyclobutyl)ethan-1-ol; Ethanol, 2-(3,3-difluorocyclobutyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-(3,3-Difluorocyclobutyl)Ethan-1-Ol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data including HPLC purity, GC analysis, NMR, and MS confirmation to ensure identity, strength, and composition. Certificates of Analysis (COA) documenting all release specifications are available for each lot. Our quality commitment supports cGMP and ISO standards for reliable sourcing in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.