Description

4-(Aminomethyl)-5,5,5-Trifluoropentanoic Acid Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its trifluoromethyl and amino acid functionalities. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting metabolic and central nervous system disorders. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of fluorinated drug candidates, where its unique structure enables the fine-tuning of pharmacokinetic properties such as metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates.
• Protease Inhibitor Research: Used in the development of novel inhibitors for enzymes like proteases, leveraging the aminomethyl moiety for binding.
• Peptidomimetics & Bioisosteres: Serves as a valuable scaffold in creating peptide mimics, where the trifluoromethyl group acts as a bioisostere for enhanced stability and lipophilicity.
• Agrochemical Synthesis: Employed in the research and development of advanced fluorinated pesticides and herbicides.
• Material Science: Potential monomer or modifier in the synthesis of specialty polymers with unique surface properties.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	4-(Aminomethyl)-5,5,5-Trifluoropentanoic Acid Hydrochloride
CAS No.	1052404-68-8
Molecular Formula	C7H11ClF3NO2
Molecular Weight	233.61 g/mol
Synonyms	5,5,5-Trifluoro-4-(aminomethyl)pentanoic acid hydrochloride; 4-(Aminomethyl)-5,5,5-trifluoropentanoic acid HCl; 5,5,5-Trifluoronorvaline hydrochloride derivative; 4-(Aminomethyl)-5,5,5-trifluorovaleric acid hydrochloride; (4-Aminomethyl-5,5,5-trifluoropentanoic acid) hydrochloride; γ-Trifluoromethyl-δ-aminovaleric acid hydrochloride; 4-(Aminomethyl)-5,5,5-trifluoropentanoic acid monohydrochloride
EINECS	Contact for details

Quality Control

Our production of 4-(Aminomethyl)-5,5,5-Trifluoropentanoic Acid Hydrochloride adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure compliance with exacting customer specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent high purity for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under dry, inert conditions to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.