Description

3-Chloro-4-(Hydroxymethyl)Phenylboronic Acid Pinacol Ester is a high-value, protected boronic acid derivative crucial for modern synthetic chemistry. This compound serves as a key synthetic intermediate, offering enhanced stability and solubility for complex cross-coupling reactions. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for constructing advanced molecular scaffolds and active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs) via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific chlorinated phenyl structures.
• Material Science Research: Employed in the development of organic electronic materials, such as polymers and small molecules for OLEDs and sensors.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and bioconjugates for target identification and binding studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Item	Detail
Product Name	3-Chloro-4-(Hydroxymethyl)Phenylboronic Acid Pinacol Ester
CAS No.	1051316-34-7
Molecular Formula	C₁₃H₁₈BClO₃
Molecular Weight	268.54 g/mol
Synonyms	3-Chloro-4-(hydroxymethyl)benzeneboronic acid pinacol ester; (3-Chloro-4-(hydroxymethyl)phenyl)boronic acid pinacol ester; 2-(3-Chloro-4-(hydroxymethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol [3-chloro-4-(hydroxymethyl)phenyl]boronate; 3-Chloro-4-(hydroxymethyl)phenylboronic acid, pinacol ester; Boronic acid, B-[3-chloro-4-(hydroxymethyl)phenyl]-, 1,1-dimethylethyl ester (9CI)
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-(Hydroxymethyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.