Description

4-[(3,4-Difluorophenoxy)Methyl]Piperidinehydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1050509-63-1. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and other therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in drug discovery, process development, and commercial-scale production.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process chemistry for constructing complex molecular scaffolds.
• Medicinal Chemistry Research: Serves as a versatile precursor for structure-activity relationship (SAR) studies and lead optimization.
• Contract Manufacturing (CMO/CDMO): Supplied to contract organizations for cGMP-compliant production of clinical trial materials and commercial APIs.
• Chemical Reference Standard: Used as a high-purity standard for analytical method development and quality control in pharmaceutical labs.

Basic Information

Product Name	4-[(3,4-Difluorophenoxy)Methyl]Piperidinehydrochloride
CAS No.	1050509-63-1
Molecular Formula	C12H15ClF2NO
Molecular Weight	262.70 g/mol
Synonyms	4-[(3,4-Difluorophenoxy)methyl]piperidine hydrochloride; 1-[(3,4-Difluorophenoxy)methyl]piperidin-4-ium chloride; 4-[(3,4-Difluorophenoxy)methyl]piperidine HCl; Piperidine, 4-[(3,4-difluorophenoxy)methyl]-, hydrochloride; 1050509-63-1; 4-(3,4-Difluorophenoxymethyl)piperidine hydrochloride
EINECS	Contact for details

Quality Control

Our 4-[(3,4-Difluorophenoxy)Methyl]Piperidinehydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, to ensure compliance with stringent pharmaceutical-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development and commercial projects requiring ICH stability data and can supply material suitable for cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.