Description

2-[(4-Fluorophenoxy)Methyl]Pyrrolidine Hydrochloride is a high-purity organic building block and pharmaceutical intermediate of significant commercial and research interest. Its molecular structure, featuring a fluorinated aromatic ether linked to a pyrrolidine moiety, makes it a valuable synthon for constructing more complex molecules, particularly in medicinal chemistry. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and for process optimization.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, due to the pyrrolidine scaffold.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides where the fluorophenoxy group can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis or as a component in metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function or receptor interactions.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Academic & Institutional Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies or structure-activity relationships (SAR).

Basic Information

Product Name	2-[(4-Fluorophenoxy)Methyl]Pyrrolidine Hydrochloride
CAS No.	1050509-51-7
Molecular Formula	C11H14FNO • HCl
Molecular Weight	231.69 g/mol (Free base: 195.23 g/mol)
Synonyms	2-[(4-Fluorophenoxy)methyl]pyrrolidine HCl; 1-(4-Fluorophenoxymethyl)pyrrolidine hydrochloride; Pyrrolidine, 2-[(4-fluorophenoxy)methyl]-, hydrochloride; 4-Fluorophenoxy methyl pyrrolidine hydrochloride; (4-Fluorophenoxymethyl)pyrrolidine HCl; 1050509-51-7; 2-(4-Fluorophenoxymethyl)pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our 2-[(4-Fluorophenoxy)Methyl]Pyrrolidine Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using a desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.