Description

Fmoc-α-Me-Gly(Pentynyl)-Oh is a specialized, non-proteinogenic Fmoc-protected amino acid building block featuring a pentynyl side chain. This compound is critical for the solid-phase synthesis of peptides and peptidomimetics, enabling the introduction of alkyne "click chemistry" handles for subsequent bioconjugation or cyclization. It is primarily utilized by researchers and manufacturers in pharmaceutical R&D and biotechnology for developing novel therapeutic agents, diagnostic probes, and advanced biomaterials.

Application

• Peptide Synthesis: A key building block in Fmoc-based solid-phase peptide synthesis (SPPS) for incorporating non-natural amino acids.
• Click Chemistry: The alkyne functional group enables efficient Huisgen 1,3-dipolar cycloaddition (copper-catalyzed or strain-promoted) with azides for bioconjugation.
• Peptidomimetic Drug Discovery: Used to create structurally modified peptide analogs with enhanced stability, bioavailability, or target affinity.
• Chemical Biology Probes: Synthesis of activity-based probes or affinity tags for studying protein function and interactions.
• Macrocyclic Peptide Libraries: Facilitates the synthesis of constrained peptides via intramolecular cyclization for screening against therapeutic targets.
• Polymer-Supported Synthesis: Employed in the development of functionalized resins and materials for combinatorial chemistry.

Basic Information

Product Name	Fmoc-α-Me-Gly(Pentynyl)-Oh
CAS No.	1050501-65-9
Molecular Formula	C24H25NO4
Molecular Weight	391.46 g/mol
Synonyms	Fmoc-α-methylglycine(pentynyl)-OH; N-(9-Fluorenylmethoxycarbonyl)-2-amino-2-methyl-5-hexynoic acid; Fmoc-α-Me-Gly(Pentynyl)-OH; Fmoc-2-amino-2-methyl-5-hexynoic acid; Fmoc-Amg(Pentynyl)-OH; (R/S)-N-Fmoc-2-amino-2-methyl-5-hexynoic acid; Fmoc-protected pentynyl alanine analog; Non-natural Fmoc amino acid building block
EINECS	Contact for details

Quality Control

Our Fmoc-α-Me-Gly(Pentynyl)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support pre-clinical and early-phase pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	95.0% - 102.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.