Description

3-([(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino)-3-(4-Isopropylphenyl)Propanoic Acid Hydrate is a high-purity, protected amino acid derivative essential for advanced peptide synthesis and pharmaceutical research. This compound serves as a critical building block for the controlled introduction of the 4-isopropylphenylalanine moiety into complex molecular architectures. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the sequential assembly of custom peptide sequences on resin supports.
• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates featuring non-natural amino acid motifs.
• Peptidomimetic Drug Design: Used to incorporate hydrophobic, bulky side chains into peptide backbones to enhance metabolic stability, receptor binding affinity, and bioavailability.
• Bioconjugation and Labeling: The reactive carboxylic acid group allows for site-specific conjugation to other molecules, such as fluorescent dyes, polymers, or carrier proteins.
• Chemical Biology Research: Employed in the study of protein-protein interactions, enzyme substrates, and the development of peptide-based probes and inhibitors.
• Custom Peptide Service Production: A standard inventory item for CROs and CDMOs offering bespoke peptide manufacturing services to the biotech industry.

Basic Information

Product Name	3-([(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino)-3-(4-Isopropylphenyl)Propanoic Acid Hydrate
CAS No.	1049746-57-7
Molecular Formula	C27H27NO5 · xH2O
Molecular Weight	445.51 g/mol (anhydrous basis)
Synonyms	Fmoc-4-isopropylphenylalanine hydrate; Fmoc-4-iPr-Phe-OH hydrate; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-isopropyl-L-phenylalanine hydrate; (2S)-3-(4-Isopropylphenyl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid hydrate; Fmoc-Phe(4-iPr)-OH hydrate; Nα-Fmoc-4-isopropyl-L-phenylalanine; Fmoc-L-Phe(4-iPr)-OH · H2O
EINECS	Contact for details

Quality Control

Our 3-([(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino)-3-(4-Isopropylphenyl)Propanoic Acid Hydrate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and KF titration for water content, to ensure it meets the exacting standards required for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic nature, the container should be allowed to reach ambient temperature before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤5.0% w/w
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.