Description

(R)-α-Propynyl-Proline-Hcl is a high-purity, non-natural amino acid derivative featuring a chiral proline backbone modified with a propynyl group. This compound is a critical chiral building block and intermediate in modern pharmaceutical research and development, enabling the synthesis of complex, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, particularly in the areas of protease inhibitors and other targeted drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs).
• Protease Inhibitor Development: Used in the research and construction of potential inhibitors for various proteolytic enzymes.
• Peptidomimetics: Acts as a constrained scaffold for designing peptide mimics with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand in catalytic asymmetric reactions.
• Medicinal Chemistry Research: Provides a versatile building block for structure-activity relationship (SAR) studies and lead optimization.
• Bioconjugation & Probe Synthesis: The alkyne functionality allows for click chemistry applications, useful in creating chemical probes for biological studies.

Basic Information

Product Name	(R)-α-Propynyl-Proline-Hcl
CAS No.	1049733-10-9
Molecular Formula	C8H12ClNO2
Molecular Weight	189.64 g/mol
Synonyms	(R)-2-(Prop-2-yn-1-yl)pyrrolidine-2-carboxylic acid hydrochloride; (R)-α-Propynylproline hydrochloride; (2R)-2-(Prop-2-yn-1-yl)pyrrolidine-2-carboxylic acid hydrochloride; (R)-1-(Prop-2-ynyl)proline hydrochloride; Proline, 2-(2-propynyl)-, hydrochloride, (R)-; (R)-2-Propynylproline HCl; (R)-Propargylproline hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-α-Propynyl-Proline-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.