Description

2-Bromo-4-Iodophenyl Trifluoromethyl Ether, also known as 2-Bromo-4-Iodo-Alpha,Alpha,α-Trifluoroanisole, is a high-value, multi-halogenated aromatic ether building block. Its unique structure, featuring bromine, iodine, and a trifluoromethoxy group, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and advanced materials sectors who require precise functionalization for drug discovery and specialty polymer synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the halogen and trifluoromethoxy groups contribute to biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing liquid crystal molecules and organic light-emitting diode (OLED) materials, enhancing electronic properties and thermal stability.
• Cross-Coupling Reactions: The bromine and iodine substituents make it an excellent substrate for sequential palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira), allowing for complex molecular architecture construction.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of the trifluoromethoxy group in medicinal and materials chemistry.
• Ligand & Catalyst Development: Potential precursor for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	2-Bromo-4-Iodophenyl Trifluoromethyl Ether
CAS No.	1049731-04-5
Molecular Formula	C7H3BrF3IO
Molecular Weight	366.90 g/mol
Synonyms	2-Bromo-4-Iodo-Alpha,Alpha,α-Trifluoroanisole; 1-Bromo-2-(Trifluoromethoxy)-4-Iodobenzene; 2-Bromo-4-Iodo(Trifluoromethoxy)benzene; 2-Bromo-1-Iodo-4-(Trifluoromethoxy)benzene; 4-Bromo-2-Iodophenyl Trifluoromethyl Ether; Benzene, 1-bromo-2-(trifluoromethoxy)-4-iodo-; (2-Bromo-4-iodophenoxy)Trifluoromethane
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Iodophenyl Trifluoromethyl Ether is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring consistency and traceability for demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.