Description

3-Bromo-4-Trifluoromethoxyanisole is a high-purity, multi-functional aromatic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of bromine, methoxy, and trifluoromethoxy substituents, which enables precise molecular modifications and the introduction of key pharmacophores. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used to construct advanced herbicide and pesticide molecules, leveraging the stability and lipophilicity imparted by the trifluoromethoxy group.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers and liquid crystals with tailored electronic properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to form new carbon-carbon and carbon-heteroatom bonds.
• Fluorine Chemistry: Acts as a stable source of the trifluoromethoxy (OCF3) group, a valuable moiety for modulating the metabolic stability, bioavailability, and binding affinity of bioactive molecules.

Basic Information

Product Name	3-Bromo-4-Trifluoromethoxyanisole
CAS No.	1049730-91-7
Molecular Formula	C8H6BrF3O2
Molecular Weight	271.04 g/mol
Synonyms	1-Bromo-2-methoxy-5-(trifluoromethoxy)benzene; 2-Methoxy-5-(trifluoromethoxy)phenyl bromide; 3-Bromo-4-(trifluoromethoxy)anisole; Anisole, 3-bromo-4-(trifluoromethoxy)-; 5-Bromo-2-methoxy-1-(trifluoromethoxy)benzene
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Trifluoromethoxyanisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.