Description

4-Bromo-2-(Trifluoromethoxy)Phenylboronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. This compound matters for its role as a key intermediate in the Suzuki-Miyaura cross-coupling reaction, enabling the efficient construction of complex biaryl structures. Pharmaceutical, agrochemical, and advanced materials researchers need it for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing trifluoromethoxy and bromo substituents for enhanced bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the boronic acid group facilitates the introduction of the phenyl moiety into complex heterocyclic systems.
• Material Science: Serves as a building block for creating organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and OFETs (Organic Field-Effect Transistors), due to its ability to form conjugated structures.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and as a scaffold for creating novel organocatalysts.
• Chemical Biology & Proteomics: Utilized in the synthesis of molecular probes and activity-based protein profiling (ABPP) agents for studying biological pathways and drug-target interactions.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CROs (Contract Research Organizations) serving the global life sciences industry.

Basic Information

Product Name	4-Bromo-2-(Trifluoromethoxy)Phenylboronic Acid
CAS No.	1048990-22-2
Molecular Formula	C7H5BBrF3O3
Molecular Weight	284.83 g/mol
Synonyms	[4-Bromo-2-(trifluoromethoxy)phenyl]boronic acid; 2-Trifluoromethoxy-4-bromophenylboronic acid; (4-Bromo-2-(trifluoromethoxy)phenyl)boronic acid; 4-Bromo-2-trifluoromethoxyphenylboronic acid; B-[4-Bromo-2-(trifluoromethoxy)phenyl]boronic acid; 4-Bromo-α,α,α-trifluoro-o-anisylboronic acid; Boronic acid, B-[4-bromo-2-(trifluoromethoxy)phenyl]-
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Trifluoromethoxy)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.