Description

Lasofoxifene -D-Glucuronide is a major, pharmacologically relevant metabolite of the selective estrogen receptor modulator (SERM) Lasofoxifene. This compound is critical for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics (PK), and bioanalytical method validation. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in advanced drug discovery and development programs for women's health and oncology.

Application

• Reference Standard for Bioanalysis: Serves as a certified reference material (CRM) for the quantitative analysis of Lasofoxifene and its metabolites in biological matrices (plasma, serum, urine) using LC-MS/MS and HPLC methods.
• Pharmacokinetic & Metabolism Studies: Essential for investigating the absorption, distribution, metabolism, and excretion (ADME) profile of Lasofoxifene in preclinical and clinical research.
• Drug Impurity Profiling: Used as an impurity standard to monitor and control the quality of Lasofoxifene active pharmaceutical ingredient (API) during manufacturing.
• In Vitro Enzyme Assays: Employed in studies to understand glucuronidation pathways and interactions with UDP-glucuronosyltransferase (UGT) enzymes.
• Regulatory Submissions: Provides essential data to support regulatory filings (e.g., with FDA, EMA) for new drug applications (NDAs) and investigational new drugs (INDs).

Basic Information

Product Name	Lasofoxifene -D-Glucuronide
CAS No.	1048953-95-2
Molecular Formula	C34H41NO9S
Molecular Weight	639.76 g/mol
Synonyms	Lasofoxifene D-Glucuronide; (5R,6S)-6-Phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-yl β-D-Glucopyranosiduronic Acid; Fablyn Glucuronide; CP-336,156 Glucuronide; Lasofoxifene Glucuronide Metabolite; Lasofoxifene β-D-Glucuronide
EINECS	Contact for details

Quality Control

Every batch of Lasofoxifene -D-Glucuronide is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) that include data for identity, purity (HPLC), and specified impurities. Our quality protocols are designed to meet the stringent requirements for pharmaceutical reference standards, supporting GLP and GMP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.