Description

4-(3-(Trifluoromethyl)Phenyl)-1H-1,2,3-Triazole-5-Carbonitrile is a high-value, heterocyclic organic building block characterized by its trifluoromethylphenyl and nitrile-functionalized triazole core. This compound matters as a versatile and critical intermediate in modern synthetic chemistry, enabling the development of novel molecules with enhanced biological activity and physicochemical properties. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for constructing complex active ingredients, particularly in the discovery of new drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and anti-inflammatory compounds.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve metabolic stability and lipophilicity.
• Material Science Precursor: Serves as a building block for advanced functional materials, including liquid crystals, organic semiconductors, and metal-organic frameworks (MOFs).
• Chemical Biology Probe: Utilized in click chemistry and bioconjugation strategies due to the reactive triazole moiety, facilitating the study of biological processes.
• Organic Synthesis Scaffold: Employed in academic and industrial R&D for constructing complex heterocyclic libraries for high-throughput screening.

Basic Information

Product Name	4-(3-(Trifluoromethyl)Phenyl)-1H-1,2,3-Triazole-5-Carbonitrile
CAS No.	1047724-33-3
Molecular Formula	C10H5F3N4
Molecular Weight	238.17 g/mol
Synonyms	4-[3-(Trifluoromethyl)phenyl]-1H-1,2,3-triazole-5-carbonitrile; 1H-1,2,3-Triazole-5-carbonitrile, 4-[3-(trifluoromethyl)phenyl]-; 4-(3-(Trifluoromethyl)phenyl)-1,2,3-triazole-5-carbonitrile; 5-Cyano-4-(3-trifluoromethylphenyl)-1,2,3-triazole; 4-(α,α,α-Trifluoro-m-tolyl)-1H-1,2,3-triazole-5-carbonitrile
EINECS	Contact for details

Quality Control

Our 4-(3-(Trifluoromethyl)Phenyl)-1H-1,2,3-Triazole-5-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.