Description

Ambrisentan-D10 is a deuterium-labeled analog of the selective endothelin receptor antagonist, Ambrisentan. This stable isotope-labeled compound is essential for precise quantitative analysis in pharmacokinetic and metabolic studies, ensuring data accuracy and reliability. It is primarily used by pharmaceutical research and development laboratories, contract research organizations (CROs), and academic institutions engaged in advanced bioanalytical method development and drug metabolism research.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the accurate quantification of Ambrisentan in biological matrices using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
• Pharmacokinetic (PK) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Metabolite Identification & Profiling: Used as a reference compound to identify and characterize metabolites of Ambrisentan, aiding in understanding its metabolic pathways.
• Bioanalytical Method Development & Validation: A key component in developing and validating robust, sensitive, and specific analytical methods compliant with GLP and FDA/EMA guidelines.
• Drug-Drug Interaction Studies: Facilitates research into potential interactions between Ambrisentan and other co-administered pharmaceuticals.
• Reference Material for Quality Control: Acts as a certified reference material for the quality control and assurance of Ambrisentan in pharmaceutical formulations.

Basic Information

Product Name	Ambrisentan-D10
CAS No.	1046116-27-1
Molecular Formula	C22H12D10N2O4
Molecular Weight	384.48 g/mol
Synonyms	Ambrisentan-d10; 5-(2,3,5,6,7,8,9,10,11,12-Decadeuterio-4-propoxyphenyl)-1,3-dihydro-1-(4-morpholinylcarbonyl)-2H-imidazol-2-one; (2S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic Acid-d10 (common mis-association); Deuterated Ambrisentan; Ambrisentan Internal Standard
EINECS	Contact for details

Quality Control

Our Ambrisentan-D10 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, chemical purity (HPLC), isotopic purity (NMR/MS), and residual solvents. We support research compliant with GLP and cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (Chemical Purity)
Isotopic Purity	≥98.0 atom % D
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.