Description

Topotecan-D6 Hydrochloride is a deuterated isotopologue of the established topoisomerase I inhibitor, Topotecan, where six hydrogen atoms are replaced with deuterium. This compound is primarily utilized as a high-value internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on oncology drug development and clinical research.

Application

• Bioanalytical Internal Standard: Critical for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) quantification of Topotecan in biological matrices (plasma, serum, tissue).
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles.
• Clinical Research Support: Used in the development and validation of robust analytical assays for clinical trial sample analysis.
• Pharmaceutical Quality Control: Supports impurity profiling and stability-indicating methods for drug substance and product analysis.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as the ideal spike-in standard for achieving high-precision quantitative results.

Basic Information

Product Name	Topotecan-D6 Hydrochloride
CAS No.	1044746-98-6
Molecular Formula	C23H17D6N3O5 • HCl
Molecular Weight	474.92 g/mol (Hydrochloride salt)
Synonyms	(S)-10-[(Dimethylamino)methyl-d6]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride; Deuterated Topotecan HCl; Topotecan-d6 HCl; 9-Dimethylamino-10-[(dimethyl-d6-amino)methyl]-(S)-camptothecin hydrochloride; HY-13768A-d6; SKF 104864A-d6 Hydrochloride
EINECS	Contact for details

Quality Control

Our Topotecan-D6 Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic enrichment, and related substances. We adhere to relevant industry guidelines for reference standard materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D6)	≥ 98.0 atom % D
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.